LET'S TALK ABOUT FREE OPINION

Free Opinion represents one of the five dimensions of freedom of this journal. The current table of contents includes excellent original papers, review articles, letters, flashback and reflections papers, in addition to an opinion piece article dissecting the shortcomings of the WHO Classification of pituitary tumors. Opinion pieces represent a channel for expressing personal but scientifically founded views on hypotheses, terminology, papers, diagnostics, politics, or anything else related to neuropathology. Thus far, Free Neuropathology has received only a few opinion pieces over the past years. This may appear surprising since controversial discussions and deviating views are traditionally considered the bedrock of scientific progress, as there is nothing in and around science that cannot be challenged. On the other hand, it is understandable, because deviating views are often controversial and, rather than welcomed, may be met with exclusion from citations, grant money, and involvement in collaborative research proposals. Accordingly, articles challenging established scientific views are often authored by senior/retired scientists who are relatively more economically independent and occupationally stable, whereas younger, less established authors, unfortunately, may be professionally less secure—thus, leading to less representation. Free Neuropathology promotes free and open scientific discussion by everyone. Thus, if you disagree with a general belief or a bold statement, we encourage you to contribute your fresh views as an Opinion Piece article to this journal, thereby promoting egalitarian discussion and providing everyone with a seat at the table.

Werner Paulus <werner.paulus@uni-muenster.de>
Editor, Free Neuropathology

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RECENT PAPERS

ORIGINAL PAPERS

Heterogeneity of DNA methylation profiles and copy number alterations in 10782 adult-type glioblastomas, IDH-wildtype

David E. Reuss, Daniel Schrimpf, Asan Cherkezov, Abigail K. Suwala, Tereza Lausová, Matija Snuderl, David Capper, Martin Sill, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Andreas von Deimling

Blocking TGF-β- and Epithelial-to-Mesenchymal Transition (EMT)-mediated activation of vessel-associated mural cells in glioblastoma impacts tumor angiogenesis

Luisa Merk, Katja Regel, Hermann Eckhardt, Marietheres Evers, Ali El-Ayoubi, Michel Mittelbronn, Marcel Krüger, Jean-Jacques Gérardy, Andreas F. Mack, Ulrike Naumann

Cellular activation patterns of CD10+ fibro-adipogenic progenitors across acquired disease states in human skeletal muscle biopsies

Peter W. Schutz, Simon Cheung, Lin Yi, Fabio M. V. Rossi

Deep RNA sequencing of muscle tissue reveals absence of viral signatures in dermatomyositis

Victor M. Corman, Corinna Preusse, Julia Melchert, Olivier Benveniste, Randi Koll, Hans-Hilmar Goebel, Terry C. Jones, Christian Drosten, Ulrike Schara-Schmidt, Sarah Leonard-Louis, Werner Stenzel, Josefine Radke

Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer's disease

Keith A. Josephs, Shunsuke Koga, Nirubol Tosakulwong, Stephen D Weigand, Trang Thu Nha Pham, Matt Baker, Jennifer L. Whitwell, Rosa Rademakers, Leonard Petrucelli, Dennis W. Dickson

Reference on copy number variations in pleomorphic xanthoastrocytoma: Implications for diagnostic approach

David E. Reuss, Daniel Schrimpf, Damian Stichel, Azadeh Ebrahimi, Chris Dampier, Kenneth Aldape, Matija Snuderl, David Capper, Martin Sill, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Andreas von Deimling

REVIEW

Neuropathology and epilepsy surgery – 2024 update

Ingmar Blümcke

HIV and COVID-19: two pandemics with significant (but different) central nervous system complications

Shino Magaki, Ting Zhang, Karam Han, Hilda Mirbaha, William H. Yong, Cristian Achim, Gregory Fishbein, Michael C. Fishbein, Omai Garner, Noriko Salamon, Christopher K. Williams, Miguel A. Valdes-Sueiras, Jeffrey J. Hsu, Theodoros Kelesidis, Glenn E. Mathisen, Helen Lavretsky, Elyse J. Singer, Harry V. Vinters

OPINION PIECE

Pituitary adenoma classification: Tools to improve the current system

William Charles McDonald

FLASHBACK

A historical look using virtual microscopy: the first case report of adrenomyeloneuropathy (AMN)

Herbert Budka

Considering the myelin-centric hypothesis: insights from Budka's historical adrenomyeloneuropathy case report

Ettore Salsano, Chiara Benzoni

Adrenomyeloneuropathy (AMN): myelinopathy or axonopathy? Comment on: Considering the myelin-centric hypothesis: insights from Budka's historical adrenomyeloneuropathy case report by E. Salsano and C. Benzoni

Herbert Budka

LETTER

Searching for a cut-off point for p53 immunohistochemistry as evidence of TP53 mutations

Ilay Caliskan, Rufei Lu, Cristine Szu Lyn Ding, Francineide Sadala de Souza, Arie Perry, Tarik Tihan

REFLECTIONS

How and why I fell into neuropathology

Jean Jacques Hauw

MEETING ABSTRACTS

63rd Annual Meeting of the Canadian Association of Neuropathologists - Association canadienne des neuropathologistes (CANP-ACNP): October 18th–21st 2023 Montreal, QC

GENERAL INFORMATION

Why is the journal called Free Neuropathology and what exactly does free mean?

Free for authors means that there is no article processing fee.
Free for readers means that the journal is published open-access without paywalls or any other restrictions of access. Together, these two features constitute what is called diamond open access. There is no revenue, no financial donation, no commercial advertising and no budget. Any expenses (editorial office, travelling, promotion, software, technical infrastructure etc.) are covered by academic institutions.
Free from publisher means that the journal takes care of all activities that traditionally are carried out by publishers, including but not restricted to copyediting, layout, permanent archiving of papers, maintenance of website, and promotion. This is based on the insight that commercial publishers are primarily interested in profit rather than in science, which has led to an economical and ethical crisis in scientific publishing. We feel that we can perform these activities more efficiently and more passionately than publishers do. For example, we are able to publish papers in the final format within three days after acceptance, including careful copyediting and layout. This is accomplished by our dedicated layout/copyediting board of enthusiastic young colleagues.
Free formatting means that the journal refrains from exuberant formal requirements and extremely detailed instructions for authors, which abound in many scientific journal. However, the journal places much emphasis on a professional and appealing appearance of papers and supports consistent formatting within the paper according to authors’ preferences. Naturally our production software is free software that we can run as we wish, adapt, write tools and redistribute them to others.
Free opinion means that in addition to traditional categories of papers such as original papers, review articles and letters, the journal publishes opinion pieces expressing personal or minority (yet scientifically founded) views, and that it encourages frank scholarly discussion among authors and readers, among the editorial board members, and among scientists and the public. On our website we utilize the open source software called Hypothes.is which introduces a sentence-level annotation layer over any paper: comments from anyone about anything and visible for anyone.

If you’d like to make up your own mind about this project, head to the journal’s website at freeneuropathology.org where you’ll find out more about our publication model, our editorial board, FAQ, free access to all papers published so far, and more.

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